报告题目：Rationally-designed Iron Oxide Nanoparticles as Efficient MRI contrast Agents

报告人:    Yuping Bao, Associate Professor

Chemical and Biological Engineering, The University of Alabama, Tuscaloosa, AL35487

时间：2015年6月16日(周二)  09: 30         

地点：中国科学院力学研究所主楼344会议室

报告摘要：

Magnetic resonance imaging (MRI) offers a powerful, non-invasive tool for brain tumor imaging and therapy monitoring. The use of contrast agents significantly enhances the image contrasts, yielding better resolution. T1 positive contrast agents are mainly paramagnetic Gadolinium (Gd) complexes, which shorten the longitudinal relaxation time (T1) and generate a brighter image. T2 negative contrast agents, primarily superparamagnetic iron oxide nanoparticles, produce a darker image by shortening the transverse relaxation time (T2). Compared to the well-studied Gd-based contrast agents, the correlation between the nanoparticle parameters and corresponding relaxivities are not well understood. In this presentation, we will utilize a suite of magnetic nanoparticles with well-designed parameters to address the correlation between the nanoparticle parameters and relaxivities. The hydrophilic coating thickness directly impacts the r2 relaxivity, but shown minimal effects on r1 relaxivity. In particular, the nanoparticle shape plays an important role as MRI contract agents. Along with the exploration of the potential of iron oxide nanoparticles as MRI contrast agents, the reproductive toxicity of these nanoparticles were also investigated on Drosophila fly, which will also be discussed in the talk.

报告人简介：

Dr. Yuping Bao is currently an Associate Professor of Chemical and Biological Engineering at The University of Alabama. She received her B.S. in Chemistry from East China University of Science and Technology, and then she studied her master in Physics Department at Tongji University, Shanghai, China. In 2006, Bao received her Ph.D. in Materials Science and Engineering and a Ph.D. Dual Degree in Nanotechnology focusing on Bioengineering from University of Washington. After two years postdoctoral study in the Center for Integrated Nanotechnology at Los Alamos National Laboratory, she joined the Department of Chemical and Biological Engineering at the University of Alabama, Tuscaloosa in 2008. In 2009, she was named as a Reichhold-Shumaker fellow and became an adjunct Faculty in Biological Science. Her current research interests are focused on rationally designed nanomaterials for biomedical applications. She is a recipient of 2010 Ralph Powe Junior Faculty Enhancement Award, and received a National Science foundation (NSF) Career Award in 2012.

报告联系人：沈楠  (office@lnm.imech.ac.cn 82543935)